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Where are the advantages and disadvantages of the three common extrusion granulators?

January 02, 2020 09:03:30 Source: Pharmaceutical Network Popularity: 7292


[ Industry News of Food Machinery and Equipment Network ] Granulation refers to the operation of powder, molten liquid, aqueous solution and other materials into particles with a certain shape and size. At present, the granulation processes used by pharmaceutical factories include extrusion granulation and shear granulation.
Among them, the extrusion granulation method refers to a method in which a pharmaceutical powder is firstly mixed with an excipient in a prescription, and then a binder is used to make a soft material, and then the soft material is granulated through a sieve with a certain size by forced extrusion.
The industry indicates that in the process of extrusion granulation, making soft materials (kneading) is a key step. The degree of wetness and softness of soft materials should be appropriate. Many productions are mastered by experience. Clamping with hands can form clumps without sticking hands, and light pressure with fingers can crack to degrees. The amount of wetting agent or adhesive depends on the nature of the material.
At present, extrusion granulators on the market include spiral extrusion, rotary extrusion, swing extrusion and other granulation equipment . It has different features and functions.
Screw extrusion granulator
Among them, the screw extrusion granulator is characterized in that the extrusion screw can be cooled or heated; the extrusion barrel adopts a split structure, and the barrel can be easily opened and the cleaning is easy by removing the bolt. In addition, the spiral extrusion granulator can be equipped with a cutting knife to adjust the relevant speed to obtain short granules with the required length. At present, screw extrusion granulators are mainly used in rubber additives, food additives, plastic additives, catalysts, pesticides, dyes, pigments, daily chemicals, pharmaceuticals and other industries that need to be granulated.
Screw extrusion granulator
Rotary extrusion type granulator is used to force uniformly mixed soft materials under the squeeze of a roller to force the materials through a screen and be cut by a scraper to obtain cylindrical particles of uniform length. It is characterized by low extrusion temperature rise, small extrusion pore size and large extrusion output, and is especially suitable for granulation of viscous materials. However, there are also reactions from users. In terms of viscous Chinese medicine soft material granulation, the rotary extrusion granulator has a severe heat during the extrusion process, and the soft material is too dry. In addition, it is easy to adhere during centrifugal granulation. Control the speed, time and air volume of centrifugal granulation.
Swing extrusion granulator
Swing extrusion granulator is a granulation equipment designed for pharmaceutical, food, health care and other industries. The machine granulates at room temperature. When working, the powder is added to the hopper and directly made into granules, which are molded in one operation, which saves costs and improves material quality. The granules produced are bright and clean, with moderate hardness, which is convenient for tablet making, packaging and storage, and capsule making.
According to the industry, the swing extrusion granulator has low energy consumption, low noise, high output, convenient operation and convenient maintenance; the drum is easy to disassemble and easy to clean. The screen is easy to replace; the mechanical transmission system is completely enclosed in the machine body, which is safe to operate; the place in contact with the material is made of stainless steel and has the advantages of durability and other advantages, and is currently widely used. However, the swing extrusion granulator is not suitable for solid, liquid, slurry or grinding.
In recent years, with the continuous development of pharmaceutical and other industries, granulation requirements have been continuously improved, and performance requirements have become higher and higher. In the purchase of granulation equipment, more emphasis has been placed on quality and energy saving. However, at present, the problems of low capacity and high energy consumption of granulation equipment are very prominent. With the continuous promotion of policies such as energy conservation and environmental protection, granulation equipment enterprises need to continuously upgrade and upgrade equipment and processes to meet the needs of pharmaceutical companies.

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